Curcumin-Artesunate Based Polymeric Nanoparticle; Antiplasmodial and Toxicological Evaluation in Murine Model

Antiplasmodial Activity and Toxicological Assessment of Curcumin PLGA-Encapsulated Nanoparticles

Curcumin is a polyphenolic pigment isolated from the rhizomes of Curcuma longa (turmeric), a medicinal plant widely used in the ancient Indian and Chinese medicine. The antiplasmodial activity of curcumin is often hampered by its fast metabolism and poor water solubility, thus its incorporation into a delivery system could circumvent this problem. This study aimed to evaluate the in vivo antipl...

In vivo toxicological evaluation of polymeric nanocapsules after intradermal administration.

Polymeric nanocarriers have shown great promise as delivery systems. An alternative strategy has been to explore new delivery routes, such as intradermal (i.d.), that can be used for vaccines and patch-based drug delivery. Despite their many advantages, there are few toxicity studies, especially in vivo. We report a safety assessment of biodegradable poly(ɛ-caprolactone) lipid-core nanocapsules...

Polymeric curcumin nanoparticle pharmacokinetics and metabolism in bile duct cannulated rats.

The objective of this study was to compare the pharmacokinetics and metabolism of polymeric nanoparticle-encapsulated (nanocurcumin) and solvent-solubilized curcumin formulations in Sprague-Dawley (SD) rats. Nanocurcumin is currently under development for cancer therapy. Since free, unencapsulated curcumin is rapidly metabolized and excreted in rats, upon intravenous (i.v.) administration of na...

teacher educator evaluation model

اگرکیفیت معلم کلاس برای بهبودیادگیری دانش آموزحیاتی است،پس کیفیت اساتیددانشجو-معلمان، یابه عبارتی معلمین معلمان نیزبرای پیشرفت آموزش بسیارمهم واساسی است.ناگفته پیداست که یک سیستم مناسب آموزش معلمان ،معلمین با کیفیتی را تربیت خواهدکرد.که این کار منجربه داشتن مدارس خوب، ودرنتیجه نیروی کارماهرتروشهروندبهتربرای جامعه خواهدشد. اساتیددانشجو-معلمان نقشی بسیارمهم را در سیستم اموزش معلمان درسراسرجهان ای...

Recommandations for Toxicological Evaluation of Nanoparticle Medicinal Products